For some, happiness is the smell of freshly baked cookies; for others, it's Smiley Eau de Toilette, the world's first antidepressant perfume (happytherapy.com). With notes of bergamot, patchouli and musk, this natural formula derived from pure cocoa extract is said to activate the brain's happiness receptors: Just max out your bliss by spritzing the unisex fragrance for a don't-worry, be-happy vibe whenever the mood strikes. The sleek bottle designed by cutting-edge French designer Ora-Ito will keep even the most discerning fashionista smiling—if a little smugly. This could be a good time to break up with your therapist. —Laura Osborne